1977
An American Cardiologist, Dr. C. Orian Truss (1922 - 2009), presented a paper "Tissue injury induced by Candida albicans: mental and neurological manifestations" at the Eighth Annual Scientific Symposium of the
Academy of Orthomolecular Psychiatry held in Toronto. The paper was published in 1978. Followed by papers in 1980, 1981, and 1984.
1983
Five year later, Dr. Truss published a book called "The Missing Diagnosis".
1984
Another American physician, Dr. William G. Crook noticed the impressive results of Dr. Truss's treatment on one of his patients. Initially skeptical, he digged into the subject, and published "The Yeast Connection" one year later. The book became an immediate best-seller.
1986 - 1990
At the time, the medical community widely dismissed the work of Truss & Crook, presenting it as "pseudoscientific". Excepted in two well-thought editorials. In a commentary published in 1986 by the Journal of the American Medical Association (JAMA), Dr. Edward R. Blonz stated: "It is imperative that well-designed studies are undertaken to unravel this mystery and help determine if there is any substance to these claims". In 1990, Dr. John E. Bennett noted in a New England Journal of Medicine editorial: “Even more damaging is the profession's apparent refusal to study chronic candidiasis”.
1990 - 2005
The hypothesis was largely forgotten by the medical community. Excepted by a growing community of physicians who believed in it, but were presented as pseudoscientic, alternative medicine practitioners, or even charlatans, by their peers.